ISOFLURANE AND PROPOFOL FOR LONG-TERM SEDATION IN THE INTENSIVE-CARE UNIT - A CROSSOVER STUDY

被引：51

作者：

MILLANE, TA ^{[1
]}

BENNETT, ED ^{[1
]}

GROUNDS, RM ^{[1
]}

机构：

[1] ST GEORGE HOSP, DEPT INTENS CARE, LONDON SW17 0RE, ENGLAND

来源：

ANAESTHESIA | 1992年 / 47卷 / 09期

关键词：

INTENSIVE CARE; ANESTHETICS; INTRAVENOUS; PROPOFOL; VOLATILE; ISOFLURANE;

D O I：

10.1111/j.1365-2044.1992.tb03254.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Propofol and isoflurane have been reported recently to offer better sedation than alternative agents in patients who require long‐term ventilation in the Intensive Care Unit. This is the first report of a direct comparison between propofol and isoflurane. Twenty‐four patients predicted to require artificial ventilation for at least 48 h were entered into a randomised crossover study to monitor sedation quality and time to recovery from sedation. There were no significant differences between the two agents in either end‐point, with over 95% optimal sedation achieved by the use of each drug. Few adverse events were noted. Technological advances in the administration of volatile agents as long‐term sedatives in the Intensive Care Unit may facilitate their more widespread use. Copyright © 1992, Wiley Blackwell. All rights reserved

引用

页码：768 / 774

页数：7

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