HIPPOCAMPAL MOSSY FIBER DISTRIBUTION DOES NOT CORRELATE WITH 2-WAY ACTIVE-AVOIDANCE PERFORMANCE IN BACKCROSS LINES DERIVED FROM INBRED MOUSE STRAINS DBA/2 AND C3H

被引：7

作者：

HOFFMANN, HJ

WENKEL, R

SCHICKNICK, H

BERNSTEIN, HG

SCHWEGLER, H

机构：

[1] INST NEUROBIOL,DEPT NEUROMORPHOL,O-3010 MAGDEBURG,GERMANY

[2] UNIV FREIBURG,INST ANAT,W-7800 FREIBURG,GERMANY

来源：

BRAIN RESEARCH | 1992年 / 589卷 / 01期

关键词：

HIPPOCAMPUS; MOSSY FIBER; ACTIVE AVOIDANCE PERFORMANCE; SHUTTLE-BOX; MOUSE; GENETIC VARIATION;

D O I：

10.1016/0006-8993(92)91181-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To elucidate the relation of genetically induced variations in two-way active avoidance performance and the extent of the hippocampal infra/intrapyramidal mossy fiber system (IIP-Mf) in inbred mouse strains DBA/2 (high performance, small IIP-Mf) and C3H (low performance, large IIP-Mf) we investigated a backcross line containing the DBA/2-derived genetic determinants for high avoidance performance in a C3H background. In the seventh backcross generation variations in performance analogous to the original strains were observed whereas the extent of mossy fibers was nearly homogeneous. This result suggests that both variables are determined by separate genetic factors at least in these strains and that differences in mossy fiber distribution are not an essential prerequisite for different active avoidance performance.

引用

页码：171 / 174

页数：4

共 13 条

[1] SPATIAL AND NONSPATIAL SPONTANEOUS-ALTERNATION AND HIPPOCAMPAL MOSSY FIBER DISTRIBUTION IN 9 INBRED MOUSE STRAINS [J].