THE 21-AMINOSTEROID U-74389G PROTECTS THE ANTIOXIDANT ENZYMES IN THE ISCHEMIA REPERFUSION-INDUCED RAT-BRAIN DAMAGE

被引：12

作者：

FARBISZEWSKI, R

CHWIECKO, M

USTYMOWICZ, J

机构：

[1] Department of Analytical Chemistry, Medical Academy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1994年 / 270卷 / 2-3期

关键词：

21-AMINOSTEROID (U-74389G); ANTIOXIDANT ENZYME; BRAIN ISCHEMIA REPERFUSION;

D O I：

10.1016/0926-6917(94)90070-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antioxidant enzymatic system in the ischemia/reperfusion induced brain injury in rats after U-74389G administration was evaluated. Ischemia/reperfusion caused a decrease in the activities of superoxide dismutase and glutathione reductase, as well as of total and free sulfhydryl groups, while thiobarbituric acid-reactive substances became elevated. Administration of U-74389G lead to restoring to normal values of ah above parameters. Protective effect of the drug in ischemia/reperfusion induced brain injury has been suggested.

引用

页码：263 / 265

页数：3

共 14 条

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[2]

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[4]

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