DEVELOPMENT OF ANGIOTENSIN-II ANTAGONISTS WITH EQUIPOTENT AFFINITY FOR HUMAN AT(1) AND AT(2) RECEPTOR SUBTYPES

被引：9

作者：

GLINKA, TW ^{[1
]}

DELASZLO, SE ^{[1
]}

SIEGL, PKS ^{[1
]}

CHANG, RS ^{[1
]}

KIVLIGHN, SD ^{[1
]}

SCHORN, TS ^{[1
]}

FAUST, KA ^{[1
]}

CHEN, TB ^{[1
]}

ZINGARO, GJ ^{[1
]}

LOTTI, VJ ^{[1
]}

GREENLEE, WJ ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,RES LABS,DEPT PHARMACOL,W POINT,PA 19486

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 19期

关键词：

D O I：

10.1016/0960-894X(94)85036-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The quinazolinone sulfonylcarbamate L-163,579 (9) is a potent, balanced antagonist of the binding of angiotensin II (Ang II) to human AT(1) and AT(2) receptors. This antagonist produces a long-lasting blockade of Ang II-induced presser response in both rats and dogs after oral administration.

引用

页码：2337 / 2342

页数：6

共 17 条

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[12]

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[15] ANGIOTENSIN-II RECEPTOR SUBTYPES [J].

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CHIU, AT ;

HERBLIN, WF ;

WONG, PC ;

SMITH, RD .

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[16] ANGIOTENSIN-II RECEPTORS AND FUNCTIONAL CORRELATES [J].

TIMMERMANS, PBMWM ;

BENFIELD, P ;

CHIU, AT ;

HERBLIN, WF ;

WONG, PC ;

SMITH, RD .

AMERICAN JOURNAL OF HYPERTENSION, 1992, 5 (12) :S221-S235

[17] RATIONALE FOR THE CHEMICAL DEVELOPMENT OF ANGIOTENSIN-II RECEPTOR ANTAGONISTS [J].

WEXLER, RR ;

CARINI, DJ ;

DUNCIA, JV ;

JOHNSON, AL ;

WELLS, GJ ;

CHIU, AT ;

WONG, PC ;

TIMMERMANS, PBMWM .

AMERICAN JOURNAL OF HYPERTENSION, 1992, 5 (12) :S209-S220

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