THE COST-EFFECTIVENESS OF ALPHA-INTERFERON IN THE TREATMENT OF CHRONIC ACTIVE HEPATITIS-C

被引:46
作者
SHIELL, A
BRIGGS, A
FARRELL, GC
机构
[1] WESTMEAD HOSP,DEPT GASTROENTEROL & HEPATOL,WESTMEAD,NSW 2145,AUSTRALIA
[2] UNIV SYDNEY,DEPT MED,WESTMEAD,NSW 2145,AUSTRALIA
关键词
D O I
10.5694/j.1326-5377.1994.tb125830.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To model the costs and effects of alpha interferon in the treatment of chronic active hepatitis C. Design: A Markov modelling process to simulate the costs and outcomes in hypothetical cohorts of patients treated with and without alpha interferon. Outcome measures: Costs per life saved and per life-year gained. Results: On the basis of assumptions formulated about the disease processes and response to treatment, treatment with alpha interferon results in a discounted cost per life-year gained of $33230 in patients with cirrhosis at the start of treatment and $71950 in patients without advanced liver disease. The result is sensitive to the assumptions made about the long term effectiveness of alpha interferon. Conclusions: Alpha interferon is an expensive drug. Its effectiveness is clouded by uncertainty about the long term impact of the drug on the natural history of the disease. If adopted, its use should be monitored to allow the long term cost effectiveness of the drug to be evaluated properly.
引用
收藏
页码:268 / 272
页数:5
相关论文
共 41 条
  • [1] ALTER HJ, 1990, J GASTROEN HEPATOL, V1, P78
  • [2] ALTER HJ, 1989, CURRENT PERSPECTIVES, P83
  • [3] HEPATITIS-C - AND MILES TO GO BEFORE WE SLEEP
    ALTER, MJ
    SAMPLINER, RE
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) : 1538 - 1540
  • [4] BECK JR, 1983, MED DECIS MAKING, V3, P411
  • [5] Cairns J, 1992, Health Econ, V1, P76, DOI 10.1002/hec.4730010111
  • [6] CAMMA C, 1992, HEPATOLOGY, V16, pA131
  • [7] COMPARISON OF 1 OR 3 MU OF INTERFERON ALFA-2B AND PLACEBO IN PATIENTS WITH CHRONIC NON-A, NON-B HEPATITIS
    CAUSSE, X
    GODINOT, H
    CHEVALLIER, M
    CHOSSEGROS, P
    ZOULIM, F
    OUZAN, D
    HEYRAUD, JP
    FONTANGES, T
    ALBRECHT, J
    MESCHIEVITZ, C
    TREPO, C
    [J]. GASTROENTEROLOGY, 1991, 101 (02) : 497 - 502
  • [8] HEPATOCELLULAR-CARCINOMA IN ITALIAN PATIENTS WITH CIRRHOSIS
    COLOMBO, M
    DEFRANCHIS, R
    DELNINNO, E
    SANGIOVANNI, A
    DEFAZIO, C
    TOMMASINI, M
    DONATO, MF
    PIVA, A
    DICARLO, V
    DIOGUARDI, N
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (10) : 675 - 680
  • [9] CONTE D, 1992, HEPATOLOGY, V16, pA60
  • [10] TREATMENT OF CHRONIC HEPATITIS-C WITH RECOMBINANT INTERFERON-ALFA - A MULTICENTER RANDOMIZED, CONTROLLED TRIAL
    DAVIS, GL
    BALART, LA
    SCHIFF, ER
    LINDSAY, K
    BODENHEIMER, HC
    PERRILLO, RP
    CAREY, W
    JACOBSON, IM
    PAYNE, J
    DIENSTAG, JL
    VANTHIEL, DH
    TAMBURRO, C
    LEFKOWITCH, J
    ALBRECHT, J
    MESCHIEVITZ, C
    ORTEGO, TJ
    GIBAS, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) : 1501 - 1506