SYNTHESIS OF AN ANALOG OF BIOSYNTHETIC PRECURSOR IA OF LIPID-A BY AN IMPROVED METHOD - A NOVEL ANTAGONIST CONTAINING 4 (S)-3-HYDROXY FATTY-ACIDS

被引：26

作者：

FUKASE, K ^{[1
]}

LIU, WC ^{[1
]}

SUDA, Y ^{[1
]}

OIKAWA, M ^{[1
]}

WADA, A ^{[1
]}

MORI, S ^{[1
]}

ULMER, AJ ^{[1
]}

RIETSCHEL, ET ^{[1
]}

KUSUMOTO, S ^{[1
]}

机构：

[1] FORSCHUNGSINST BORSTEL,D-23845 BORSTEL,GERMANY

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 41期

关键词：

D O I：

10.1016/0040-4039(95)01433-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of an analog of a biosynthetic precursor of lipid A containing four (S)-3-hydroxytetradecanoic acids was effected via an improved synthetic route to investigate the relationship between the bioactivity and the chirality of the 3-hydroxy fatty acid residues in lipid A. The S-analog inhibited endotoxin-induced interleukin-6 (IL-6) production from human peripheral whole blood cells more strongly than the natural-type biosynthetic precursor with (R)-hydroxy acids, a known antagonist of LPS-induced cytokine release in human peripheral blood mononuclear cells.

引用

页码：7455 / 7458

页数：4

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