CONFORMATION OF CHOLINERGIC MOLECULES RELEVANT TO ACETYLCHOLINESTERASE

被引:55
作者
CHOTHIA, C
PAULING, P
机构
[1] William Ramsay and Ralph Forster Laboratories, University College London
关键词
D O I
10.1038/223919a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Crystal structure analyses of several cholinergic molecules, combined with their relative rates of hydrolysis by acetylcholinesterase, allow one to determine the conformation of labile cholinergic molecules relevant to their interaction with the enzyme. © 1969 Nature Publishing Group.
引用
收藏
页码:919 / &
相关论文
共 11 条
[1]   IMPORTANCE OF STEREOISOMERISM IN MUSCARINIC ACTIVITY [J].
BECKETT, AH ;
CLITHEROW, JW ;
HARPER, NJ .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1963, 15 (06) :362-+
[2]   STRUCTURE OF ACETYLCHOLINE AND OTHER SUBSTRATES OF CHOLINERGIC SYSTEMS [J].
CANEPA, FG ;
PAULING, P ;
SORUM, H .
NATURE, 1966, 210 (5039) :907-&
[3]   CONFORMATIONS OF ACETYLCHOLINE [J].
CHOTHIA, C ;
PAULING, P .
NATURE, 1968, 219 (5159) :1156-&
[4]  
CHOTHIA CH, 1969, CHEM COMMUN, V30, P746
[5]  
CHOTHIA CH, 1969, CHEM COMMUN, V30, P626
[6]   DESCRIPTION OF STERIC RELATIONSHIPS ACROSS SINGLE BONDS [J].
KLYNE, W ;
PRELOG, V .
EXPERIENTIA, 1960, 16 (12) :521-523
[7]  
PAULING P, 1968, STRUCTURAL CHEMISTRY, P555
[8]   ANALOGS OF PARASYMPATHETIC NEUROEFFECTORS .2. COMPARATIVE PHARMACOLOGICAL STUDIES OF ACETYLCHOLINE ITS THIO + SELENO ANALOGS + THEIR HYDROLYSIS PRODUCTS [J].
SCOTT, KA ;
MAUTNER, HG .
BIOCHEMICAL PHARMACOLOGY, 1964, 13 (06) :907-&
[9]   CRYSTAL AND MOLECULAR STRUCTURE OF ACETYLSELENOCHOLINE IODIDE [J].
SHEFTER, E ;
KENNARD, O .
SCIENCE, 1966, 153 (3742) :1389-&
[10]  
SHEFTER E, 1969, ACTA CRYSTALL A-CRYS, VA 25, pS201