INTERGROUP ANTIGENIC RELATIONSHIPS AMONG ARBOVIRUSES MANIFESTED BY A MEXICAN STRAIN OF PATOIS VIRUS AND VIRUSES OF BUNYAMWERA C CALIFORNIA CAPIM AND GUAMA GROUPS

Zarate, M. L., R. H. Geiger, R. E. Shope and W. F. Scherer (Cornell Univ. Medical College, 1300 York Ave., New York, N. Y. 10021). Intergroup antigenic relationships among arboviruses manifested by a Mexican strain of Patois virus and viruses of the Bunyamwera, C, California, Capim and Guama groups. Amer. J. Epid ., 1968, 88: 273-286-A strain of Patois virus, isolated from Mexican Culex mosquitoes in 1963, was found to cross-react antigenically with viruses of the Bunyamwera, C, California, Guama and Capim groups of arboviruses. These intergroup relationships were manifested by hemagglutination-inhibition and in a few instances by neutralization tests, but not by complement-fixation tests. The Mexican strain of Patois virus passed 50 but not 10 millimicron filters and was pathogenic for suckling mice inoculated intracranially or subcutaneously. In early but not later mouse passages, it consistently killed weanling mice inoculated S.C. and weanling hamsters inoculated i.c. No disease was evident in Guinea pigs or rabbits, but antibodies were produced. It caused CPE in human HeLa cells but not in mouse L cell, primary chicken embryonic or hamster kidney cell cultures. © 1968, by The Johns Hopkins University.