DYSTROPHIN IS LOCALIZED TO THE PLASMA-MEMBRANE OF HUMAN SKELETAL-MUSCLE FIBERS BY ELECTRON-MICROSCOPIC CYTOCHEMICAL STUDY

被引：64

作者：

CARPENTER, S ^{[1
]}

KARPATI, G ^{[1
]}

ZUBRZYCKAGAARN, E ^{[1
]}

BULMAN, DE ^{[1
]}

RAY, PN ^{[1
]}

WORTON, RG ^{[1
]}

机构：

[1] HOSP SICK CHILDREN,DEPT GENET,TORONTO M5G 1X8,ONTARIO,CANADA

来源：

MUSCLE & NERVE | 1990年 / 13卷 / 05期

关键词：

dystrophin; electron‐microscopic immunocytochemistry; human skeletal muscle; immunoperoxidase; plasmalemma;

D O I：

10.1002/mus.880130503

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Electron‐microscopic immunoperoxidase technique revealed plasmalemmal localization of dystrophin in microscopically normal human skeletal muscle fibers obtained from nine routine diagnostic muscle biopsies. There was no evidence of periodicity of the immunoreactive product nor was there any evidence of immunostaining in any organelle besides the plasma membrane. Dystrophin appears to be a cytoskeletal protein associated with the plasmalemma. Its function is presumed to be the maintenance of the mechanical stability of the surface membrane so that it can withstand the normal contraction‐induced stresses without disruption. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：376 / 380

页数：5

共 18 条

[1] IMMUNOSTAINING OF SKELETAL AND CARDIAC-MUSCLE SURFACE-MEMBRANE WITH ANTIBODY AGAINST DUCHENNE MUSCULAR-DYSTROPHY PEPTIDE
ARAHATA, K
ISHIURA, S
ISHIGURO, T
TSUKAHARA, T
SUHARA, Y
EGUCHI, C
ISHIHARA, T
NONAKA, I
OZAWA, E
SUGITA, H
[J]. NATURE, 1988, 333 (6176) : 861 - 863
[2] BONILLA E, 1986, NEUROLOGY, V36, P171
[3] DUCHENNE MUSCULAR-DYSTROPHY - DEFICIENCY OF DYSTROPHIN AT THE MUSCLE-CELL SURFACE
BONILLA, E
SAMITT, CE
MIRANDA, AF
HAYS, AP
SALVIATI, G
DIMAURO, S
KUNKEL, LM
HOFFMAN, EP
ROWLAND, LP
[J]. CELL, 1988, 54 (04) : 447 - 452
[4] MOLECULAR-BIOLOGY OF DUCHENNE MUSCULAR-DYSTROPHY
BROWN, RH
HOFFMAN, EP
[J]. TRENDS IN NEUROSCIENCES, 1988, 11 (11) : 480 - 484
[5] DUCHENNE MUSCULAR-DYSTROPHY - PLASMA-MEMBRANE LOSS INITIATES MUSCLE-CELL NECROSIS UNLESS IT IS REPAIRED
CARPENTER, S
KARPATI, G
[J]. BRAIN, 1979, 102 (MAR) : 147 - 161
[6] MEMBRANE-CYTOSKELETON INTERACTION
GEIGER, B
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 737 (3-4) : 305 - 341
[7] PROTEIN-SEQUENCE OF DMD GENE IS RELATED TO ACTIN-BINDING DOMAIN OF ALPHA-ACTININ
HAMMONDS, RG
[J]. CELL, 1987, 51 (01) : 1 - 1
[8] DYSTROPHIN - THE PROTEIN PRODUCT OF THE DUCHENNE MUSCULAR-DYSTROPHY LOCUS
HOFFMAN, EP
BROWN, RH
KUNKEL, LM
[J]. CELL, 1987, 51 (06) : 919 - 928
[9] SUBCELLULAR FRACTIONATION OF DYSTROPHIN TO THE TRIADS OF SKELETAL-MUSCLE
HOFFMAN, EP
KNUDSON, CM
CAMPBELL, KP
KUNKEL, LM
[J]. NATURE, 1987, 330 (6150) : 754 - 758
[10] SMALL-CALIBER SKELETAL-MUSCLE FIBERS DO NOT SUFFER DELETERIOUS CONSEQUENCES OF DYSTROPHIC GENE-EXPRESSION
KARPATI, G
CARPENTER, S
[J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1986, 25 (04): : 653 - 658

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