BIOPHARMACEUTICAL STUDIES OF FATTY SUSPENSION SUPPOSITORIES .1. SPREADING INSITU

被引：16

作者：

RUTTENKINGMA, JJ ^{[1
]}

POLDERMAN, J ^{[1
]}

BLAEY, CJD ^{[1
]}

机构：

[1] GORLAEUS LABS,SUBFAC PHARM,DEPT PHARMACEUT,WASSENAARSEWEG 76,NL-2300 RA LEIDEN,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1979年 / 3卷 / 01期

关键词：

D O I：

10.1016/0378-5173(79)90048-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present publication an investigation is described about the qualitative and quantitative determination of the spreading of suppository vehicles and compounds suspended in suppositories in situ in the rat. The influence of variables such as particle size, particle concentration and solubility of the suspended compound are studied. Next to these parameters, factors such as the pressure of the rectum wall and the viscosity of the suppository vehicle at body temperature seem to be important for the spreading behaviour of the suppositories. Therefore, on theoretical grounds the spreading of the suppositories in vivo cannot be predicted. © 1979.

引用

页码：39 / 53

页数：15

共 17 条

[1]

BEVERNAGE KBM, 1973, FIP C STOCKHOLM, P184

[2]

BEVERNAGE KBM, 1973, PHARM WEEKBLAD, V108, P429

[3]

BLAEY CJD, 1976, PHARM ACTA HELV, V51, P186

[4]

BLAEY CJD, 1978, DRUG DESIGN, V8

[5]

BLAEY CJD, 1976, 15TH C IND PHARM GEN, P74

[6]

BLAEY CJD, 1977, PHARM ACTA HELV, V52, P11

[7]

BLAEY CJD, 1976, PHARM WEEKBL, V111, P1216

[8]

BOER AGD, 1977, FIP C HAGUE, P86

[9]

HENNIG W, 1959, REKTALE RESORPTION M

[10] RATE OF RELEASE OF MEDICAMENTS FROM OINTMENT BASES CONTAINING DRUGS IN SUSPENSION [J].

HIGUCHI, T .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1961, 50 (10) :874-&

← 1 2 →