CARDENOLIDE ANALOGS .10. CHARACTERIZATION OF CARDIAC-GLYCOSIDES BY CHEMICAL IONIZATION MASS-SPECTROMETRY

被引：32

作者：

VINE, J ^{[1
]}

BROWN, L ^{[1
]}

BOUTAGY, J ^{[1
]}

THOMAS, R ^{[1
]}

NELSON, D ^{[1
]}

机构：

[1] UNIV NEW S WALES,SCH CHEM,KENSINGTON 2033,NEW S WALES,AUSTRALIA

来源：

BIOMEDICAL MASS SPECTROMETRY | 1979年 / 6卷 / 10期

关键词：

D O I：

10.1002/bms.1200061002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The potential of chemical ionization mass spectrometry for the characterization of naturally occurring and semi‐synthetic cardiac glycosides has been investigated. Methane, isobutane and ammonia were used as reactant gases. With the exception of ouabain, the ammonia chemical ionization mass spectra of the cardiac glycosides examined in this work contained abundant [M+NH4]+ ions and abundant fragment ions formed by cleavage of glycoside bonds. Ammonia chemical ionization mass spectrometry was found to provide a rapid and sensitive method for the characterization of the products of glycosidation reactions. In contrast, the methane and isobutane chemical ionization mass spectra of the cardiac glycosides, with the exception of ouabain, did not contain protonated molecular ions and did not contain abundant fragment ions above m/z 400. Copyright © 1979 Heyden & Son Ltd

引用

页码：415 / 421

页数：7

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