PROTECTIVE ACTION OF 7 NATURAL PHENOLIC-COMPOUNDS AGAINST PEROXIDATIVE DAMAGE TO BIOMEMBRANES

被引：242

作者：

LIU, GT

ZHANG, TM

WANG, BE

WANG, YW

机构：

[1] Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 43卷 / 02期

关键词：

D O I：

10.1016/0006-2952(92)90271-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of seven phenolic compounds isolated from Salvia miltiorrhiza and peroxidative damage to liver microsomes, hepatocytes and erythrocytes of rats were studied. The results show that the seven compounds inhibited lipid peroxidation of rat liver microsomes induced by iron/cysteine and Vitamin C/NADPH. The hemolysis of rate erythrocytes induced by hydrogen peroxide was also inhibited. The degree of inhibition varied with different compounds. Among the seven compounds, the action of salvianolic acid (Sia A) was the most potent. Therefore, the protective action of Sai A against peroxidative damage to isolated rat hepatocytes and their plasma membranes was evaluated further. Malondialdehyde (MDA) production and bleb of the surface of rat hepatocytes induced by iron/cysteine were prevented by Sai A. The production of MDA and the consumption of NADPH of the plasma membrane during lipid peroxidation initiated by iron/cysteine and Vitamin C/NADPH were also inhibited. The results strongly suggest that several phenolic compounds like Sai A have a protective action against peroxidative damage to biomembranes.

引用

页码：147 / 152

页数：6

共 13 条

[1]

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[2]

Emmelot P, 1974, Methods Enzymol, V31, P75

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