STRUCTURE AND INVITRO ANTIVIRAL ACTIVITY OF TRITERPENOID SAPONINS FROM CALENDULA-ARVENSIS

被引：24

作者：

DETOMMASI, N

CONTI, C

STEIN, ML

PIZZA, C

机构：

[1] NAPLES UNIV,DIPARTIMENTO CHIM SOSTANZE NAT,VIA D MONTESANO 49,I-80131 NAPLES,ITALY

[2] UNIV ROME LA SAPIENZA,FAC MED,IST MICROBIOL,I-00185 ROME,ITALY

[3] UNIV ROME LA SAPIENZA,DIPARTIMENTO STUDI FARMACEUT,I-00185 ROME,ITALY

来源：

PLANTA MEDICA | 1991年 / 57卷 / 03期

关键词：

CALENDULA-ARVENSIS; OLEANOLIC ACID GLYCOSIDES; VESICULAR STOMATITIS VIRUS; RHINOVIRUS; ANTIVIRAL ACTIVITY;

D O I：

10.1055/s-2006-960084

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A reinvestigation of the aerial parts of Calendula arvensis afforded, in addition to the oleanolic acid glycosides 1-4 (4), the new glycoside 5 whose structure was elucidated by spectral and chemical studies and determined as 3-O-{beta-D-galactopyranosyl-(1 --> 3)[beta-D-glucopyranosyl-(1 --> 4)]-beta-D-glucopyranosyl}oleanolic acid (28 --> 1)-beta-D-glucopyranosyl ester. Furthermore, some antiviral tests were performed on glycosides 1-5 and on 5a, the hydrolysis product of 5, towards vesicular stomatitis virus (VSV) and rhinovirus (HRV) infection in cell cultures. An inhibitory effect against VSV multiplication was observed for all the compounds tested while HRV replication was significantly affected only by compound 3.

引用

页码：250 / 253

页数：4

共 12 条

[1] INTERFERON INDUCTION BY GLYCYRRHIZIN AND GLYCYRRHETINIC ACID IN MICE [J].