FUNCTIONAL CONTROL OF GASTRIN RELEASING PEPTIDE (GRP) MESSENGER-RNA IN RAT STOMACH

被引：9

作者：

DIMALINE, R ^{[1
]}

SANDVIK, AK ^{[1
]}

BARCLAY, G ^{[1
]}

DOCKRAY, GJ ^{[1
]}

机构：

[1] UNIV LIVERPOOL,DEPT PHYSIOL,PHYSIOL LAB,MRC,SECRETORY CONTROL GRP,POB 147,LIVERPOOL L69 3BX,ENGLAND

来源：

FEBS LETTERS | 1992年 / 301卷 / 03期

关键词：

GRP; STOMACH; ACID; FOOD; MESSENGER RNA; PCR;

D O I：

10.1016/0014-5793(92)80259-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gastric factors controlling abundance of mRNA encoding the important neuropeptide, gastrin releasing peptide (GRP) in rat stomach. were examined by Northern and slot blot analysis. Withdrawal of food increased antral GRP mRNA, as did treatment of fed rats with the acid inhibitory drug, omeprazole. There was no change in GRP mRNA abundance in gastric corpus. The data indicate functionally distinct populations of GRP neurons in different regions of the stomach, and control of antral neuropeptide biosynthesis by the gastric luminal contents.

引用

页码：291 / 293

页数：3

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