A NEW MACROCYCLIC LACTAM ANTIBIOTIC, BE-14106 .1. TAXONOMY, ISOLATION, BIOLOGICAL-ACTIVITY AND STRUCTURAL ELUCIDATION

被引：39

作者：

KOJIRI, K ^{[1
]}

NAKAJIMA, S ^{[1
]}

SUZUKI, H ^{[1
]}

KONDO, H ^{[1
]}

SUDA, H ^{[1
]}

机构：

[1] BANYU PHARMACEUT CO LTD, CENT RES LABS,EXPLORATORY RES,2-9-3 SHIMO MEGURO, MEGURO KU, TOKYO 153, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 06期

关键词：

D O I：

10.7164/antibiotics.45.868

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A Streptomyces strain labeled A14106 was isolated and found to produce a novel 20-membered macrocyclic lactam derivative, BE-14106, which exhibited both cytotoxic activity against murine tumor cell lines and antimicrobial activity.

引用

页码：868 / 874

页数：7

共 15 条

[1] RAPID DIFFERENTIATION BETWEEN NOCARDIA + STREPTOMYCES BY PAPER CHROMATOGRAPHY OF WHOLE-CELL HYDROLYSATES
BECKER, B
GORDON, RE
LECHEVALIER, HA
LECHEVALIER, MP
[J]. APPLIED MICROBIOLOGY, 1964, 12 (05) : 421 - +
[2] GENERAL THEORY OF CARCINOGENESIS
COMINGS, DE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (12) : 3324 - 3328
[3] HISAMATSU T, 1985, JPN J CANCER RES, V76, P1008
[4] SYNTHETIC ANALOGS OF FUMAGILLIN THAT INHIBIT ANGIOGENESIS AND SUPPRESS TUMOR-GROWTH
INGBER, D
FUJITA, T
KISHIMOTO, S
SUDO, K
KANAMARU, T
BREM, H
FOLKMAN, J
[J]. NATURE, 1990, 348 (6301) : 555 - 557
[5] MUTATION AND CANCER - STATISTICAL STUDY OF RETINOBLASTOMA
KNUDSON, AG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (04) : 820 - &
[6] ANTITUMOR-ACTIVITY OF NEW MORPHOLINO ANTHRACYCLINES
KOMESHIMA, N
TSURUO, T
UMEZAWA, H
[J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (04) : 548 - 553
[7] THE UTILIZATION OF CARBON COMPOUNDS BY SOME ACTINOMYCETALES AS AN AID FOR SPECIES DETERMINATION
PRIDHAM, TG
GOTTLIEB, D
[J]. JOURNAL OF BACTERIOLOGY, 1948, 56 (01) : 107 - 114
[8] 3'-HYDROXYESORUBICIN - SYNTHESIS AND ANTITUMOR-ACTIVITY
PRIEBE, W
NEAMATI, N
PEREZSOLER, R
[J]. JOURNAL OF ANTIBIOTICS, 1990, 43 (07) : 838 - 846
[9] SHIRLING E B, 1968, International Journal of Systematic Bacteriology, V18, P279
[10] SHIRLING E. B., 1966, INT J SYST BACTERIOL, V16, P313

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