A TANDEM RADICAL MACROCYCLIZATION - RADICAL TRANSANNULATION STRATEGY TO THE TAXANE RING-SYSTEM

被引：88

作者：

HITCHCOCK, SA ^{[1
]}

PATTENDEN, G ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(00)61300-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of the iodo-trienone (8 b) with tri-n-butyltin hydride in the presence of AIBN is shown to produce the taxane ring system (11) by way of a tandem radical macrocyclisation - radical transannulation sequence, i.e. (8 b) --> (9) --> (11) (cf. Scheme 1).

引用

页码：4843 / 4846

页数：4

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