5-NITRO-2'-DEOXYURIDINE 5'-PHOSPHATE - A MECHANISM-BASED INHIBITOR OF THYMIDYLATE SYNTHETASE

被引：21

作者：

MAGGIORA, L

CHANG, CCTC

TORRENCE, PF

MERTES, MP

机构：

[1] UNIV KANSAS,SCH PHARM,DEPT MED CHEM,LAWRENCE,KS 66045

[2] NIAMDD,CHEM LAB,BETHESDA,MD 20205

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1981年 / 103卷 / 11期

关键词：

D O I：

10.1021/ja00401a042

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：3192 / 3198

页数：7

共 45 条

[1] THE SYNTHESIS OF NUCLEOSIDE AND NUCLEOTIDE ANALOGS DERIVED FROM URIDINE [J].

BANNISTER, B ;

KAGAN, F .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (13) :3363-3368

[2] AMINO-ACID SEQUENCE AT FDUMP BINDING-SITE OF THYMIDYLATE SYNTHETASE [J].

BELLISARIO, RL ;

MALEY, GF ;

GALIVAN, JH ;

MALEY, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (06) :1848-1852

[3]

BIGGE CF, UNPUBLISHED

[4] 5-(ALPHA-BROMOACETYL)-2'-DEOXYURIDINE 5'-PHOSPHATE - AFFINITY LABEL FOR THYMIDYLATE SYNTHETASE [J].

BROUILLETTE, CB ;

CHANG, CTC ;

MERTES, MP .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (12) :1541-1544

[5] ELUCIDATION OF DETAILED STRUCTURES OF NATIVE AND DENATURED TERNARY COMPLEXES OF THYMIDYLATE SYNTHETASE VIA F-19 NMR [J].

BYRD, RA ;

DAWSON, WH ;

ELLIS, PD ;

DUNLAP, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (24) :7478-7486

[6]

CHIKUMA T, 1978, CHEM PHARM BULL, V26, P1746

[7] PARTITION ANALYSIS AND CONCEPT OF NET RATE CONSTANTS AS TOOLS IN ENZYME-KINETICS [J].

CLELAND, WW .

BIOCHEMISTRY, 1975, 14 (14) :3220-3224

[8]

CRUSBERG TC, 1970, J BIOL CHEM, V245, P5292

[9] STRUCTURES OF REVERSIBLE AND IRREVERSIBLE COMPLEXES OF THYMIDYLATE SYNTHETASE AND FLUORINATED PYRIMIDINE NUCLEOTIDES [J].

DANENBER.PV ;

LANGENBA.RJ ;

HEIDELBE.C .

BIOCHEMISTRY, 1974, 13 (05) :926-933

[10] THYMIDYLATE SYNTHETASE - TARGET ENZYME IN CANCER CHEMOTHERAPY [J].

DANENBERG, PV .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 473 (02) :73-92

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