SYNTHESIS OF IODOBUPRENORPHINE FOR USE IN RADIOIMMUNOASSAY

被引：6

作者：

DEBRABANDERE, L

VANBOVEN, M

DAENENS, P

机构：

[1] Laboratory of Toxicology, Leuven, 3000

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 08期

关键词：

125-IODINE; IODOBUPRENORPHINE; CHLORAMINE-T; IODO-BEADS(R); RADIOIMMUNOASSAY;

D O I：

10.1002/jlcr.2580310803

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of [I-125]iodobuprenorphine is described. This compound has been used as a tracer molecule in the development of a nev radioimmunoassay for buprenorphine. The parameters that effect the direct iodination of buprenorphine using sodium [I-127]iodide, in the presence of either chloramine-T or Iodo-Beads(R), were previously studied. The structure of iodobuenorphine was confirmed by mass spectrometry.

引用

页码：575 / 588

页数：14

共 11 条

[1] DEBRABANDERE L, 1992, J FORENSIC SCI, V37, P82
[2] DEBRABANDERE L, UNPUB
[3] PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY
GREENWOOD, FC
HUNTER, WM
[J]. BIOCHEMICAL JOURNAL, 1963, 89 (01) : 114 - &
[4] I131-LABELING OF PROTEINS BY IODINE MONOCHLORIDE METHOD
HELMKAMP, RW
CONTRERA.MA
BALE, WF
[J]. INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1967, 18 (11): : 737 - &
[5] PREPARATION OF IODINE-131 LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC ACTIVITY
HUNTER, WM
GREENWOOD, FC
[J]. NATURE, 1962, 194 (4827) : 495 - &
[6] AN ENZYMIC METHOD FOR TRACE IODINATION OF IMMUNOGLOBULINS AND OTHER PROTEINS
MARCHALONIS, JJ
[J]. BIOCHEMICAL JOURNAL, 1969, 113 (02) : 299 - +
[7] A NEW SOLID-STATE REAGENT TO IODINATE PROTEINS .1. CONDITIONS FOR THE EFFICIENT LABELING OF ANTISERUM
MARKWELL, MAK
[J]. ANALYTICAL BIOCHEMISTRY, 1982, 125 (02) : 427 - 432
[8] MASON PA, 1980, J LABELLED COMPOUNDS, V28, P1497
[9] NIEUWENHUIZEN W, 1980, BIOCHEM BIOPH RES CO, V97, P45
[10] IMPROVED METHOD FOR PREPARATION OF IODINATED ANTIGENS FOR RADIOIMMUNOASSAY
REDSHAW, MR
LYNCH, SS
[J]. JOURNAL OF ENDOCRINOLOGY, 1974, 60 (03) : 527 - 528

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