THE LIFE-SPAN OF NAIVE ALPHA/BETA T-CELLS IN SECONDARY LYMPHOID ORGANS

被引：125

作者：

VONBOEHMER, H

HAFEN, K

机构：

[1] Basel Institute for Immunology, Basel

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1993年 / 177卷 / 04期

关键词：

D O I：

10.1084/jem.177.4.891

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have determined the life span of naive CD4-8+ T cells in T cell receptor transgenic mice. We find that such cells do not divide in secondary lymphoid organs in both normal euthymic mice and T cell-deficient mice. By both continuous labeling and by chasing pulse-labeled cells, we find that the minimum life span of the naive T cells is in the order of 8 wk.

引用

页码：891 / 896

页数：6

共 24 条

[1] INTERCONVERSION OF CD45R SUBSETS OF CD4 T-CELLS INVIVO
BELL, EB
SPARSHOTT, SM
[J]. NATURE, 1990, 348 (6297) : 163 - 166
[2] BEVERLEY PCL, 1990, CURR TOP MICROBIOL, V159, P111
[3] A MONOCLONAL-ANTIBODY TO MURINE CD45R DISTINGUISHES CD4 T-CELL POPULATIONS THAT PRODUCE DIFFERENT CYTOKINES
BOTTOMLY, K
LUQMAN, M
GREENBAUM, L
CARDING, S
WEST, J
PASQUALINI, T
MURPHY, DB
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (04) : 617 - 623
[4] BUDD RC, 1987, J IMMUNOL, V138, P3120
[5] THE CELLULAR BASIS OF T-CELL MEMORY
CEROTTINI, JC
MACDONALD, HR
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1989, 7 : 77 - 89
[6] THE BULK OF THE PERIPHERAL B-CELL POOL IN MICE IS STABLE AND NOT RAPIDLY RENEWED FROM THE BONE-MARROW
FORSTER, I
RAJEWSKY, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4781 - 4784
[7] LYMPHOCYTE POPULATION-KINETICS IN THE MOUSE
FREITAS, AA
ROCHA, B
COUTINHO, AA
[J]. IMMUNOLOGICAL REVIEWS, 1986, 91 : 5 - 37
[8] KINETICS AND EFFICACY OF POSITIVE SELECTION IN THE THYMUS OF NORMAL AND T-CELL RECEPTOR TRANSGENIC MICE
HUESMANN, M
SCOTT, B
KISIELOW, P
VONBOEHMER, H
[J]. CELL, 1991, 66 (03) : 533 - 540
[9] TOLERANCE IN T-CELL-RECEPTOR TRANSGENIC MICE INVOLVES DELETION OF NONMATURE CD4+8+ THYMOCYTES
KISIELOW, P
BLUTHMANN, H
STAERZ, UD
STEINMETZ, M
VONBOEHMER, H
[J]. NATURE, 1988, 333 (6175) : 742 - 746
[10] LIMITING DILUTION ANALYSIS OF CD45RHI AND CD45RIO T-CELLS - FURTHER EVIDENCE THAT CD45RIO CELLS ARE MEMORY CELLS
LEE, WT
VITETTA, ES
[J]. CELLULAR IMMUNOLOGY, 1990, 130 (02) : 459 - 471

← 1 2 3 →