PLATELET PLASMINOGEN-ACTIVATOR INHIBITOR-1 IN PATIENTS WITH TYPE-II DIABETES

被引:39
作者
JOKL, R [1 ]
LAIMINS, M [1 ]
KLEIN, RL [1 ]
LYONS, TJ [1 ]
LOPESVIRELLA, MF [1 ]
COLWELL, JA [1 ]
机构
[1] MED UNIV S CAROLINA, DIV ENDOCRINOL DIABET & METAB, CHARLESTON, SC 29425 USA
关键词
D O I
10.2337/diacare.17.8.818
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - To compare platelet plasminogen activator inhibitor 1 (PAI-1) concentration in type II diabetic patients and healthy control subjects. RESEARCH DESIGN AND METHODS - We studied a group of 12 diabetic patients whose disease was controlled by diet or sulfonylurea therapy and a group of 17 nondiabetic control subjects. All subjects were free of clinically advanced vascular disease. PAI-1 antigen concentrations were measured in 5 X 10(8) isolated platelets, which were lysed by 1% Triton X-100. RESULTS - Mean platelet PAI-1 was significantly higher in diabetic patients (264 +/- 83 ng/5 X 10(8) platelets) compared with control subjects (202 +/- 71 ng/5 X 10(8) platelets) (P < 0.05). A significant independent positive correlation was found between platelet PAI-1 concentrations and fasting plasma specific insulin levels in the diabetic patients (r = 0.63, P = 0.03). CONCLUSIONS - These findings suggest that 1) a higher platelet PAI-1 concentration may contribute to enhanced thrombosis in type II diabetes and 2) megakaryocyte PAI-1 synthesis may be under the control oi insulin.
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收藏
页码:818 / 823
页数:6
相关论文
共 39 条
[1]   TISSUE-TYPE PLASMINOGEN-ACTIVATOR ANTIGEN AND PLASMINOGEN-ACTIVATOR INHIBITOR IN DIABETES-MELLITUS [J].
AUWERX, J ;
BOUILLON, R ;
COLLEN, D ;
GEBOERS, J .
ARTERIOSCLEROSIS, 1988, 8 (01) :68-72
[2]   TYPE 2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS, HYPERTENSION AND HYPERLIPEMIA (SYNDROME-X) - RELATION TO REDUCED FETAL GROWTH [J].
BARKER, DJP ;
HALES, CN ;
FALL, CHD ;
OSMOND, C ;
PHIPPS, K ;
CLARK, PMS .
DIABETOLOGIA, 1993, 36 (01) :62-67
[3]  
BAZZAN M, 1993, HAEMOSTASIS, V23, P38
[4]   PLATELET-RELEASE PROTEIN WHICH INHIBITS PLASMINOGEN ACTIVATORS [J].
BOOTH, NA ;
ANDERSON, JA ;
BENNETT, B .
JOURNAL OF CLINICAL PATHOLOGY, 1985, 38 (07) :825-830
[5]   PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) IN PLASMA AND PLATELETS [J].
BOOTH, NA ;
SIMPSON, AJ ;
CROLL, A ;
BENNETT, B ;
MACGREGOR, IR .
BRITISH JOURNAL OF HAEMATOLOGY, 1988, 70 (03) :327-333
[6]   VASCULAR THROMBOSIS IN TYPE-II DIABETES-MELLITUS [J].
COLWELL, JA .
DIABETES, 1993, 42 (01) :8-11
[7]   A REVIEW OF THE DEVELOPMENT OF LARGE-VESSEL DISEASE IN DIABETES-MELLITUS [J].
COLWELL, JA ;
LOPESVIRELLA, MF .
AMERICAN JOURNAL OF MEDICINE, 1988, 85 (5A) :113-118
[8]  
COLWELL JA, 1992, DIABETIC FOOT, P79
[9]  
ENTMACHER PS, 1985, JOSLINS DIABETES MEL, P278
[10]   DETECTION AND PARTIAL CHARACTERIZATION OF AN INHIBITOR OF PLASMINOGEN-ACTIVATOR IN HUMAN-PLATELETS [J].
ERICKSON, LA ;
GINSBERG, MH ;
LOSKUTOFF, DJ .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (04) :1465-1472