The effect of topical oestradiol on skin collagen of postmenopausal women

被引：85

作者：

Varila, E

Rantala, I

Oikarinen, A

Risteli, J

Reunala, T

Oksanen, H

Punnonen, R

机构：

[1] TAMPERE UNIV HOSP,DEPT OBSTET & GYNAECOL,TAMPERE,FINLAND

[2] TAMPERE UNIV HOSP,PATHOL UNIT,TAMPERE,FINLAND

[3] UNIV OULU,DEPT DERMATOL & VENEROL,OULU,FINLAND

[4] UNIV OULU,DEPT CLIN CHEM,OULU,FINLAND

[5] HELSINKI UNIV HOSP,DEPT DERMATOL & VENEROL,HELSINKI,FINLAND

[6] UNIV TAMPERE,DEPT PUBL HLTH,BIOMETRY UNIT,SF-33101 TAMPERE,FINLAND

[7] UNIV TAMPERE,DEPT CLIN MED,SF-33101 TAMPERE,FINLAND

来源：

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1995年 / 102卷 / 12期

关键词：

D O I：

10.1111/j.1471-0528.1995.tb10906.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective To examine the effect of topical oestradiol on skin collagen and elastin. Subjects Twelve postmenopausal women, aged 52 to 76 years. Interventions Topical oestradiol treatment on the skin of lower abdomen and the vehicle only on the contralateral site; once a day for three months. Main outcome measures The content of skin hydroxyproline; the levels of the carboxyterminal propeptide of human type I procollagen (PICP) and of the aminoterminal propetide of human type III procollagen (PIIINP). The number and the quality of collagen and elastic microfibrils. Results The amount of hydroxyproline in the skin significantly (P = 0.012) increased from 11.8 to 16.3 mu g (38 %) during oestradiol treatment. After treatment, the PICP level in the blister fluid was significantly (P = 0.024) higher on the treated site than on the control site. Also the level of PIIINP increased, but the change was not statistically significant. Electron microscopy showed morphologic improvement of elastic and collagen fibres, while the number of oxytalan and elaunin fibres was unchanged in light microscopy. Conclusions Topical oestradiol treatment increases the amount of skin collagen. The increase in the level of PICP and PIIINP in skin blister fluid indicates that oestradiol treatment stimulates collagen synthesis. Furthermore, our results show that topical ostradiol treatment has a greater influence on the amount than on the quality of skin collagen. On the contrary, in elastic tissue the oestradiol treatment will only result in morphologic improvement.

引用

页码：985 / 989

页数：5

共 19 条

[1]

Annala A-P., Risteli L., Koivukangas V., Autio P., Risteli J., Oikarinen A., Measurement of collagen metabolism in skin diseases. A review of old and new techniques and their clinical applications, Eur J Dermatol, 3, pp. 696-703, (1993)

[2]

Brincat M., Kabalan S., Studd J.W.W., Moniz C.F., de Trafford J., Montgomery J., A study of the decrease of skin collagen content, skin thickness, and bone mass in the postmenopausal woman, Obstet Gynecol, 70, pp. 840-845, (1987)

[3]

Brincat M., Versi E., Moniz C.F., Magos A., de Trafford J., Studd J.W.W., Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy, Obstet Gynecol, 70, pp. 840-845, (1987)

[4]

Brincat M., Versi E., O'Dowd T., Et al., Skin collagen changes in post‐menopausal women receiving oestradiol gel, Maturitas, 9, pp. 1-5, (1987)

[5]

Brincat M., Studd J.W.W., Menopause‐α multi system disease, Baillièeres Clin Obstet Gynaecol, 2, pp. 289-316, (1988)

[6]

Castelo-Branco C., Duran M., Gonzalez-Merlo J., Skin collagen changes related to age and hormone replacement therapy, Maturitas, 15, pp. 113-119, (1992)

[7]

Cotta-Pereira G., Guerra, Bittencourt-Sampaio S., Oxytalan, elaunin, and elastic fibers in the human skin, Journal of Investigative Dermatology, 66, pp. 143-148, (1976)

[8]

Hassager C., Jesen L.T., Podenphant J., Riis B.J., Christiansen C., Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones, Metabolism, 39, pp. 1167-1169, (1990)

[9]

Ihlberg L., Haukipuro K., Risteli L., Oikarinen A., Kairaluoma M., Risteli J., Collagen synthesis in skin is suppressed during wound healing, Ann Surg, 217, pp. 397-403, (1993)

[10]

Jemec G.B.E., Serup J., Short‐term effects of topical 17β‐ oestradiol on human post‐menopausal skin, Maturitas, 11, pp. 229-234, (1989)

← 1 2 →