PROSTAGLANDIN-D2 IS THE PREVAILING PROSTAGLANDIN IN THE ACUTE INFLAMMATORY EXUDATE OF URATE ARTHRITIS IN THE CHICKEN

被引：19

作者：

ANHUT, H

BRUNE, K

FROLICH, JC

PESKAR, BA

机构：

[1] UNIV BASEL,BIOCENTER,DEPT PHARMACOL,CH-4056 BASEL,SWITZERLAND

[2] DR M FISCHER BOSCH INST KLIN PHARMAKOL,D-7000 STUTTGART 50,FED REP GER

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 65卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb07837.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An acute inflammation was elicited in intertarsal joints of chicken by injection of urate crystals. Inflammatory exudates recovered at different times were assayed for prostaglandin D2(PGD2) E2 and F2α and thromboxane B2 content by specific radioimmunoassays. We found that PGD2 was the prevailing prostaglandin reaching concentrations up to 10 times in excess of PGE2. This finding was confirmed by gas chromatography‐mass spectrometry. It is concluded that PGD2 should be considered as a possible mediator of acute inflammation. 1979 British Pharmacological Society

引用

收藏

页码：357 / 359

页数：3

相关论文

共 15 条

[1] IDENTIFICATION OF PROSTAGLANDIN D2 AS A MAJOR PROSTAGLANDIN IN HOMOGENATES OF RAT-BRAIN [J].

ABDELHALIM, MS ;

HAMBERG, M ;

SJOQUIST, B ;

ANGGARD, E .

PROSTAGLANDINS, 1977, 14 (04) :633-643

[2] RADIOIMMUNOLOGICAL DETERMINATION OF PROSTAGLANDIN-D2 SYNTHESIS IN HUMAN THROMBOCYTES [J].

ANHUT, H ;

PESKAR, BA ;

WACHTER, W ;

GRABLING, B ;

PESKAR, BM .

EXPERIENTIA, 1978, 34 (11) :1494-1496

[3] RELEASE OF 15-KETO-13,14-DIHYDRO-THROMBOXANE-B2 AND PROSTAGLANDIN-D2 DURING ANAPHYLAXIS AS MEASURED BY RADIOIMMUNOASSAY [J].

ANHUT, H ;

PESKAR, BA ;

BERNAUER, W .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 305 (03) :247-252

[4] AVIAN MICROCRYSTAL ARTHRITIS .3. INVASION AND ENZYME-RELEASE FROM LEUKOCYTES AT SITE OF INFLAMMATION [J].

BRUNE, K ;

GLATT, M .

AGENTS AND ACTIONS, 1974, 4 (02) :95-100

[5] INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN [J].

FLOWER, RJ ;

HARVEY, EA ;

KINGSTON, WP .

BRITISH JOURNAL OF PHARMACOLOGY, 1976, 56 (02) :229-233

[6]

FROLICH SC, 1976, PROSTAGLANDINS, V3, P1

[7] LEUKOCYTES AND PROSTAGLANDINS IN ACUTE-INFLAMMATION [J].

GLATT, M ;

PESKAR, B ;

BRUNE, K .

EXPERIENTIA, 1974, 30 (11) :1257-1259

[8] DETECTION AND ISOLATION OF AN ENDOPEROXIDE INTERMEDIATE IN PROSTAGLANDIN BIOSYNTHESIS [J].

HAMBERG, M ;

SAMUELSS.B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :899-903

[9] ISOMERIZATION OF PROSTAGLANDIN H-2 INTO PROSTAGLANDIN D2 IN PRESENCE OF SERUM-ALBUMIN [J].

HAMBERG, M ;

FREDHOLM, BB .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 431 (01) :189-193

[10] RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND PLATELET-AGGREGATION ACTIVITY OF PROSTAGLANDINS [J].

KLOEZE, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 187 (03) :285-&