ADMITTANCE OF MEMBRANES ASSOCIATED WITH CHANNEL CONDUCTION - APPLICATION TO CHANNELS AT NONEQUILIBRIUM STEADY-STATE

The small-signal admittance of membranes associated with channel conduction is derived for a general channel model. A general channel model is represented by a set of chemical reactions with each species of the reactions representing a channel state. The membrane admittance is shown to be related to the phenomenological relaxation matrix of the reactions. If the kinetic reactions are at a non-equilibrium steady state, the relaxation matrix may have complex eigenvalues and the equivalent circuit of the membrane admittance may contain RLC or RLC-like branches. For equilibrium kinetic systems, on the other hand, the equivalent circuit contains only RL or RC branches. Thus, the membrane admittance of equilibrium channels is quite different from that of non-equilibrium channels. In particular, we show that the low frequency feature in the admittance of squid axons as observed by Fishman, Poussart, Moore & Siebenga (1977) can be obtained easily from a non-equilibrium cycling steady-state model. © 1979.