ENDOTOXIN LIPOPOLYSACCHARIDE FROM ESCHERICHIA-COLI AND ITS EFFECTS ON THE PHAGOCYTIC FUNCTION OF SYSTEMIC AND PULMONARY MACROPHAGES IN TURKEYS

被引：14

作者：

EMERY, DA

NAGARAJA, KV

SIVANANDAN, V

LEE, BW

ZHANG, CL

NEWMAN, JA

机构：

[1] Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, Paul

来源：

AVIAN DISEASES | 1991年 / 35卷 / 04期

关键词：

D O I：

10.2307/1591627

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The effect of Escherichia coli lipopolysaccharide (LPS) on the competence of pulmonary macrophages and phagocytic cells from the systemic circulation of turkeys was examined using luminol-enhanced zymosan-stimulated chemiluminescence. The results showed a rapid and accelerated oxidative burst in both systemic and pulmonary macrophages in LPS-treated turkeys that was significantly greater than in untreated controls. However, this increased oxidative metabolism induced by LPS was not associated with enhanced intracellular bacterial killing by pulmonary macrophages. Turkeys treated with LPS showed a highly significant decrease in pulmonary bactericidal activity against Staphylococcus aureus challenge, indicating a defect in pulmonary macrophage function induced by LPS.

引用

页码：901 / 909

页数：9

共 43 条

[1] Absolom D R, 1986, Methods Enzymol, V132, P95
[2] THE CELL BIOLOGY OF MACROPHAGE ACTIVATION
ADAMS, DO
HAMILTON, TA
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1984, 2 : 283 - 318
[3] ALLEN RC, 1980, LIQUID SCINTILLATION, V11, P377
[4] BALL RA, 1962, P SOC EXP BIOL MED, V110, P753, DOI 10.3181/00379727-110-27641
[5] BALTZER MI, 1991, INFECT IMMUN, V59, P689
[6] COMPARATIVE STUDIES ON TOXICITY OF ESCHERICHIA COLI LIPOPOLYSACCHARIDE ENDOTOXIN IN VARIOUS ANIMAL SPECIES
BERCZI, I
BERTOK, L
BEREZNAI, T
[J]. CANADIAN JOURNAL OF MICROBIOLOGY, 1966, 12 (05) : 1070 - +
[7] BRIGHAM KL, 1986, AM REV RESPIR DIS, V133, P913
[8] SEPTICEMIA AND LUNG INJURY
BRIGHAM, KL
BEGLEY, CJ
BERNARD, GR
HUTCHISON, AA
LOYD, JE
LUCHT, WD
MEYRICK, B
NEWMAN, JH
NIEDERMEYER, ME
OGLETREE, ML
SHELLER, JR
SNAPPER, JR
[J]. CLINICS IN LABORATORY MEDICINE, 1983, 3 (04) : 719 - 744
[9] MEDIATORS OF PULMONARY INJURY INDUCED BY INHALATION OF BACTERIAL-ENDOTOXIN
BURRELL, R
LANTZ, RC
HINTON, DE
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (01): : 100 - 105
[10] EFFECT OF ESCHERICHIA-COLI ENDOTOXINS AND ADRENOCORTICAL HORMONES ON PLASMA ENZYME-ACTIVITIES IN THE DOMESTIC-FOWL
CURTIS, MJ
JENKINS, HG
BUTLER, EJ
[J]. RESEARCH IN VETERINARY SCIENCE, 1980, 28 (01) : 44 - 50

← 1 2 3 4 5 →