LIPID-PEROXIDATION - BIOPATHOLOGICAL SIGNIFICANCE

被引：58

作者：

COMPORTI, M ^{[1
]}

机构：

[1] UNIV SIENA, INST PATOL GEN, I-53100 SIENA, ITALY

来源：

MOLECULAR ASPECTS OF MEDICINE | 1993年 / 14卷 / 03期

关键词：

D O I：

10.1016/0098-2997(93)90006-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxidation of unsaturated lipids, initially studied in the chemestry of oil and fat rancidity, has become a problem of increasing interest in the biological field, because of its proposed role in a variety of pathological conditions. The general mechanism of the process, the formation of toxic aldehydes capable to react with protein and non protein thiols, and the overall effects in cellular membranes are reviewed. The possible implications of lipid peroxidation as one of the main mechanisms of cellular damage in both toxic injury and other pathological conditions are discussed.

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页码：199 / 207

页数：9

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