SEQUENCE AND STRUCTURE SIMILARITIES OF CATHEPSIN-B FROM THE PARASITE SCHISTOSOMA-MANSONI AND HUMAN LIVER

被引：8

作者：

KLINKERT, MQ

CIOLI, D

SHAW, E

TURK, V

BODE, W

BUTLER, R

机构：

[1] FRIEDRICH MIESCHER INST,CH-4002 BASEL,SWITZERLAND

[2] JOZEF STEFAN INST,LJUBLJANA,SLOVENIA

[3] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY

来源：

FEBS LETTERS | 1994年 / 351卷 / 03期

关键词：

CATHEPSIN B; SCHISTOSOMA MANSONI; HUMAN LIVER; STRUCTURAL COMPARISON; INHIBITOR MODELING;

D O I：

10.1016/0014-5793(94)00893-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A three-dimensional structure of Schistosoma mansoni cathepsin B was modelled using the coordinates of the crystal Structure of the human liver enzyme. Both enzymes appear to share remarkable structural similarity. However, an examination of the models complexed with two synthetic inhibitors revealed differences in inhibitor binding, as confirmed by differences in the 50% inhibitory concentration of the same inhibitor.

引用

页码：397 / 400

页数：4

共 14 条

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