CHARACTERIZATION STUDY OF A DICLOFENAC SALT BY MEANS OF SEM AND FRACTAL ANALYSIS

被引：23

作者：

HOLGADO, MA ^{[1
]}

FERNANDEZHERVAS, MJ ^{[1
]}

RABASCO, AM ^{[1
]}

FINI, A ^{[1
]}

机构：

[1] UNIV BOLOGNA, IST SCI CHIM, I-40127 BOLOGNA, ITALY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 120卷 / 02期

关键词：

DICLOFENAC N-(2-HYDROXYETHYL)PYRROLIDINE; CRYSTALLIZATION MODE; SIZE AND SHAPE DESCRIPTORS; SURFACE GEOMETRY; FRACTAL DIMENSION;

D O I：

10.1016/0378-5173(94)00382-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this paper, the morphological and surface characteristics of five samples from different batches of the same salt, diclofenac/N-(2-hydroxyethyl)pyrrolidine were investigated using SEM descriptors and fractal dimensions. Two samples were crystallized from organic solvents; the others from water. This elementary difference is suitable to introduce differences in their behaviours. Salt particles obtained from organic solvents present cubic shapes and smooth surfaces. On the other hand, salt particles obtained from aqueous solutions exhibit irregular forms and rugged surfaces. Furthermore, solvent molecules are adsorbed on the particle surface during the synthesis process or become incorporated into the bulk. When these substances are subjected to thermal treatment, the solvent molecules are lost, causing a change in the external morphology of the particles. The fractal dimensions calculated from the slope of a Richardson plot were 1.14, 1.04, 1.09, 1.05 and 1.10. These results seem to indicate that the D values are not greatly affected by the mode of synthesis and solvent employed.

引用

页码：157 / 167

页数：11

共 16 条

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