CHEMICAL AND BIOACTIVE CONSTITUENTS FROM ZANTHOXYLUM SIMULANS

被引：134

作者：

CHEN, IS

WU, SJ

TSAI, IL

WU, TS

PEZZUTO, JM

LU, MC

CHAI, H

SUH, N

TENG, CM

机构：

[1] NATL CHENG KUNG UNIV,DEPT CHEM,TAINAN 70101,TAIWAN

[2] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,CHICAGO,IL

[3] NATL TAIWAN UNIV,COLL MED,INST PHARMACOL,TAIPEI 10764,TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 09期

关键词：

D O I：

10.1021/np50111a003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new benzo[c]phenanthridine alkaloids, G-methyldihydrochelerychrine [1] and 6-methylnorchelerythrine [2], together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline [3] and huajiaosimuline [4], exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.

引用

页码：1206 / 1211

页数：6

共 21 条

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