CHARACTERIZATION OF A GADOLINIUM-LABELED CHOLESTEROL DERIVATIVE AS AN ORGAN-SPECIFIC CONTRAST AGENT FOR ADRENAL MR-IMAGING

被引：11

作者：

MUHLER, A

PLATZEK, J

RADUCHEL, B

FRENZEL, T

WEINMANN, HJ

机构：

[1] Mri Contrast Media Research, Schering Ag Berlin, Berlin, 13342

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1995年 / 5卷 / 01期

关键词：

ADRENAL GLAND; CHOLESTEROL; CONTRAST ENHANCEMENT; CONTRAST MEDIA; EXPERIMENTAL STUDIES; GADOLINIUM;

D O I：

10.1002/jmri.1880050104

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose of the study was to determine if derivatization of cholesterol with a paramagnetic label could result in an organ-specific contrast agent for magnetic resonance imaging of the adrenal glands. Gadolinium-DO3A-labeled cholesterol was synthesized and the relaxivities in water and blood plasma determined at 0.47 T and 40 degrees C. Organ distribution was measured at 2 (n = 2) and 24 (n = 2) hours after intravenous injection of a 50 mu mol/kg dose of Gd-DO3A-cholesterol in rats weighing 220-240 g, T1-weighted spin-echo images were acquired at 2 T before and after injection of 50 mu mol/kg Gd-DO3A-cholesterol (n = 2) and Gd-DTPA (diethylenetriaminepentaacetic acid)-albumin (n = 2), More than 99% of the Gd-DO3A-cholesterol was found to be protein bound in bovine serum. High T1 and T2 relaxivities were found in water and plasma. High tissue concentrations of Gd-DO3A-cholesterol were found only in adrenal glands and liver. At 24 hours, adrenal gadolinium concentrations were about 10 times higher than in blood, At 2 hours after injection of Gd-DO3A-cholesterol, enhancement was 162% in adrenal glands and 146% in liver. With Gd-DTPA-albumin, enhancement values were 57% and 56%, respectively.

引用

页码：7 / 10

页数：4

共 12 条

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