CHARACTERISTICS OF BLOOD HEMOSTATIC MARKERS IN A PATIENT WITH OVARIAN HYPERSTIMULATION SYNDROME WHO ACTUALLY DEVELOPED THROMBOEMBOLISM

Objective: To investigate whether a patient with ovarian hyperstimulation syndrome (OHSS) demonstrated characteristic changes in the blood hemostatic markers before she developed thromboembolism. Design: Patients with OHSS had blood drawn to determine hemostatic markers and related factors. Patients: Twenty-three OHSS patients, including a case complicated with thromboembolism. Setting: The IVF-ET program of the Department of Obstetrics and Gynecology, The University of Akita, School of Medicine. Main Outcome Measures: Blood hemostatic markers and related factors. Results: The patient with thromboembolism demonstrated marked leukocytosis and higher levels of activation in the blood markers related to fibrinolytic system, such as alpha(2) plasmin inhibitor, plasmin-alpha(2) antiplasmin complexes, and D-dimers, before the onset of this episode. Conclusion: Marked leukocytosis and higher levels of activation of the fibrinolytic system may be the signs of imminent thromboembolism in OHSS patients.