INHALED NITRIC-OXIDE PREVENTS THE INCREASE IN PULMONARY VASCULAR-PERMEABILITY CAUSED BY HYDROGEN-PEROXIDE

被引:48
作者
POSS, WB
TIMMONS, OD
FARRUKH, IS
HOIDAL, JR
MICHAEL, JR
机构
[1] UNIV UTAH,MED CTR,DEPT PEDIAT,DIV PEDIAT CRIT CARE,SALT LAKE CITY,UT 84132
[2] VET AFFAIRS MED CTR,DEPT MED,DIV RESP CRIT CARE & OCCUPAT PULM MED,SALT LAKE CITY,UT 84132
关键词
PULMONARY VASCULAR FILTRATION COEFFICIENT; GLUCOSE OXIDASE; ACUTE RESPIRATORY DISTRESS SYNDROME;
D O I
10.1152/jappl.1995.79.3.886
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Given the interest in using inhaled nitric oxide (NO .) to treat acute lung injury and the importance of oxygen radicals in its pathogenesis, we studied the effects, in buffer-perfused isolated rabbit lungs, of inhaled NO . (24 ppm) on the injury caused by generating hydrogen peroxide with glucose and glucose oxidase (GOX). Experiments were performed at a constant pulmonary arterial pressure. GOX substantially augmented vascular permeability, as demonstrated by an increase in the lung-to-perfusate I-125-labeled albumin ratio, lavage-to-perfusate I-125-albumin wet-to-dry lung weight ratio, and pulmonary vascular filtration coefficient. Lungs treated with inhaled NO . before perfusion with GOX had lung-to-perfusate and lavage-to-perfusate I-125-albumin ratios that were not significantly different from control values and intermediate between the control and GOX groups. Inhaled NO. also prevented the increase in wet-to-dry lung weight ratio and pulmonary vascular filtration coefficient caused by GOX .. Thus inhaled NO . substantially reduced in the isolated lung the increase in pulmonary vascular permeability produced by the intravascular generation of hydrogen peroxide.
引用
收藏
页码:886 / 891
页数:6
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