HEMOGLOBIN-LEPOREBALTIMORE, A THIRD TYPE OF A DELTABETA CROSSOVER (DELTA50, BETA86)

被引：87

作者：

OSTERTAG, W

SMITH, EW

机构：

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1969年 / 10卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1969.tb00700.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new Lepore‐type hemoglobin in a person of Negro descent has been identified. In this person a minor hemoglobin (Hb‐LeporeBaltimore) was detected. An abnormal δβ‐chain was isolated and fingerprinted. This hybrid‐type protein presumably arose as a consequence of unequal crossing over between the δ and β genes, as was concluded for Hb‐LeporeBoston and Hb‐LeporeHollandia. In the new Lepore‐type hemoglobin described here the crossover could be placed between residues δ50 and β86. This type of crossover should occur with the highest frequency if crossing over is equally frequent between any nucleotide and if selection favours none of the crossover types. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：371 / &

共 13 条

[1] HUMAN ABNORMAL HEMOGLOBINS .11. A CHEMICAL STUDY OF HEMOGLOBIN LEPORE FROM A HOMOZYGOTE INDIVIDUAL [J].