ORAL TOLERANCE IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS - SERUM AND SALIVARY ANTIBODY-RESPONSES

被引:28
作者
FULLER, KA
PEARL, D
WHITACRE, CC
机构
[1] OHIO STATE UNIV,DEPT MED MICROBIOL & IMMUNOL,5072 GRAVES HALL,333 W 10TH AVE,COLUMBUS,OH 43210
[2] OHIO STATE UNIV,DEPT STAT,COLUMBUS,OH 43210
关键词
Antibody; Autoimmunity; Enzyme-linked immunosorbent assay; Experimental autoimmune encephalomyelitis; Myelin basic protein; Oral tolerance;
D O I
10.1016/0165-5728(90)90037-N
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have recently reported that the oral administration of myelin basic protein (MBP) prior to encephalitogenic challenge results in suppression of experimental autoimmune encephalomyelitis (EAE). We examined the serum and salivary antibody responses to MBP in orally tolerant rats usnig an avidin-biotin enzyme-linked immunosorbent assay. Serum anti-MBP IgA and IgG, but not IgM levels are suppressed in orally tolerant versus control rats. This suppression is time dependent and is confined to the period when animals would otherwise be manifesting EAE clinical signs. In contrast, there is an increase in salivary anti-MBP IgA levels in MBP-fed rats relative to vehicle-fed controls. Thus, MBP-induced unresponsiveness is demonstrable at the humoral level, and moreover, a discrete compartmentalization between the serum and salivary anti-MBP responses exists. © 1990.
引用
收藏
页码:15 / 26
页数:12
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