CONSTITUENTS OF PACHYGONE-OVATA AND PHARMACOLOGICAL ACTION OF ITS MAJOR LEAF ALKALOID

被引:30
作者
DASGUPTA, S
RAY, AB
BHATTACHARYA, SK
BOSE, R
机构
[1] BANARAS HINDU UNIV,INST MED SCI,DEPT MED CHEM,VARANASI 221005,UTTAR PRADESH,INDIA
[2] BANARAS HINDU UNIV,INST MED SCI,DEPT PHARMACOL,VARANASI 221005,UTTAR PRADESH,INDIA
来源
JOURNAL OF NATURAL PRODUCTS | 1979年 / 42卷 / 04期
关键词
D O I
10.1021/np50004a007
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Pachygone ovata (Menispermaceae) grows in the sandy sea shores of southern India, and its fruits are used as fish poison. Systematic fractionation of ethanolic extracts of the leaves, stems, and roots of the plant afforded five alkaloids: N-methylerotsparine (1), reticuline (2), liriodenine (5), trilobine (6), and coclaurine (7). In addition there was isolated a new amine oxide, reticuline N-oxide (3), and a cyclitol, characterized as (+)-quercitol (4). The pharmacological actions of reticuline were investigated. It showed central stimulant, hyperthermic, and spinal convulsant actions, the profile closely resembling that reported with thebaine. © 1979, American Chemical Society. All rights reserved.
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页码:399 / 406
页数:8
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