ANTIGENIC EXPRESSION OF CATHEPSIN-B IN AGED HUMAN BRAIN

被引：46

作者：

BERNSTEIN, HG

KIRSCHKE, H

WIEDERANDERS, B

SCHMIDT, D

RINNE, A

机构：

[1] MED ACAD MAGDEBURG,INST ANAT,O-3090 MAGDEBURG,GERMANY

[2] MARTIN LUTHER UNIV,INST BIOCHEM,O-4010 HALLE,GERMANY

[3] DIST HOSP PSYCHIAT,BRANDENBURG,GERMANY

[4] UNIV TROMSO,INST PATHOL,N-9001 TROMSO,NORWAY

来源：

BRAIN RESEARCH BULLETIN | 1990年 / 24卷 / 04期

关键词：

Aging; Alzheimer disease; Cathepsin B; Human brain; Immunohistochemistry;

D O I：

10.1016/0361-9230(90)90157-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The lysosomal thiol proteinase, cathepsin B, has been localized in different regions of aged human brain by use of the peroxidase-antiperoxidase technique. Cathepsin B-immunoreactive material was detected in multiple neurons of human hippocampus, neocortical area A 10, prefrontal gyrus and nuc. basalis of Meynert as well as in single white matter astrocytes. In brains of Alzheimer disease-affected subjects cathepsin B was revealed in neuritic plaques too. Possible functional consequences with regard to normal aging, neuropeptide metabolism and pathological changes are discussed. © 1990.

引用

页码：543 / 549

页数：7

共 21 条

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