MORPHINE INHIBITS CYCLIC AMP-DEPENDENT PROTEIN-KINASE AND ORNITHINE DECARBOXYLASE ACTIVITIES IN NEUROBLASTOMA-X GLIOMA HYBRID-CELLS

被引：14

作者：

BACHRACH, U ^{[1
]}

BENALAL, D ^{[1
]}

RECHES, A ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH HOSP & MED SCH,DEPT NEUROL,JERUSALEM,ISRAEL

来源：

LIFE SCIENCES | 1979年 / 25卷 / 22期

关键词：

D O I：

10.1016/0024-3205(79)90608-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of morphine on neuroblastoma x glioma hybrid cells is not limited to the inhibition of adenylate cyclase activity. It is demonstrated that in morphine-treated cells there is a marked reduction in the activity of both cyclic AMP-dependent protein kinase and ornithine decarboxylase (ODC) in response to stimulation by PGE1. The effect of morphine is to block a cascade of events which may be crucial for the normal biochemical processes in these cells. © 1979.

引用

页码：1879 / 1883

页数：5

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