CALCIUM CALMODULIN-DEPENDENT PROTEIN-KINASE MEDIATES A PATHWAY FOR TRANSCRIPTIONAL REGULATION

被引：120

作者：

KAPILOFF, MS ^{[1
]}

MATHIS, JM ^{[1
]}

NELSON, CA ^{[1
]}

LIN, CR ^{[1
]}

ROSENFELD, MG ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, SCH MED, EUKARYOT REGULATORY BIOL PROGRAM, LA JOLLA, CA 92093 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 09期

关键词：

ROUS SARCOMA VIRUS; LONG TERMINAL REPEAT; CAAT; ENHANCER BINDING PROTEIN; PROLACTIN GENE;

D O I：

10.1073/pnas.88.9.3710

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.

引用

页码：3710 / 3714

页数：5

共 38 条

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