Although the numbers of human immunodeficiency virus–infected children in the United States are among the most rapidly growing populations, pediatric patients still comprise only approximately 2% of the acquired immunodeficiency syndrome cases in developed countries. In developing nations, however, children comprise 5 to 20% of the people with acquired immunodeficiency syndrome and the impact of human immunodeficiency virus infection on infant and childhood morbidity and mortality in these countries is astounding. As the global community evolves, it is important for pediatricians to be aware of the seriousness of acquired immunodeficiency syndrome on the world's community of children. Drs. Quinn, Ruff and Halsey present a well–informed and sobering perspective on the incidence, patterns of transmission, clinical manifestations, medical management, social impact and preventive considerations regarding human immunodeficiency virus–infected children in developing nations. There are many important lessons and insights to be gained from the experiences in Africa and Haiti and we would encourage all physicians to read and think about this important article. © 1992 by Williams and Wilkins.