SYNTHESIS OF ENEDIYNES BY DIELS-ALDER ADDITION

被引:21
作者
HOPF, H
THEURIG, M
机构
[1] Institut für Organische Chemie, Technischen Universität Braunschweig, D-38106
关键词
D O I
10.1002/anie.199410991
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The hex‐3‐ene‐1,5‐diyne unit, the reaction‐initiating component of the enediyne antibiotics, was generated in the synthesis of compounds of type 3 by Diels–Alder reaction for the first time. The requisite diene 2 is easily obtained by coupling diene 1 with alkynyl Grignard reagents. Subsequent cycloaddition with dienophiles furnishes the target compounds 3. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany
引用
收藏
页码:1099 / 1100
页数:2
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