THE DISTRIBUTION OF DNA TOPOISOMERASE-II ISOFORMS IN DIFFERENTIATED ADULT-MOUSE TISSUES

被引：35

作者：

JUENKE, JM ^{[1
]}

HOLDEN, JA ^{[1
]}

机构：

[1] UNIV UTAH,DEPT PATHOL,SALT LAKE CITY,UT 84132

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1216卷 / 02期

关键词：

DNA TOPOISOMERASE-II; ISOFORM; DIFFERENTIATION; (ADULT MOUSE TISSUE);

D O I：

10.1016/0167-4781(93)90144-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibodies raised against the alpha and beta isoforms of human DNA topoisomerase II were found to react with the corresponding mouse enzymes. By using these antibodies in Western blotting experiments, it was observed that these isoforms are differentially expressed in adult mouse tissues: The alpha isoform is abundant in testis and spleen. The beta isoform is also abundant in spleen and in addition is present in kidney and liver. Type II topoisomerase is low in brain and heart. These results suggest different functions for these two isoforms of DNA topoisomerase II.

引用

页码：191 / 196

页数：6

共 21 条

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