SYNTHESIS OF THE PALMITOYLATED AND FARNESYLATED C-TERMINAL LIPOHEXAPEPTIDE OF THE HUMAN N-RAS PROTEIN BY EMPLOYING AN ENZYMATICALLY REMOVABLE URETHANE PROTECTING GROUP

Enzyme‐labile urethane protecting groups, which enable the construction of biologically important peptides relevant for cancer research, were used to synthesize characteristic lipidated partial sequences of the human N‐Ras protein for the first time. The strategy is sketched below. They are cleaved chemoselectively under very mild conditions (pH 7, 45 °C), and therefore leave extremely sensitive peptide side chains intact. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany