CLENBUTEROL, A BETA(2)-AGONIST, RETARDS WASTING AND LOSS OF CONTRACTILITY IN IRRADIATED DYSTROPHIC MDX MUSCLE

被引：33

作者：

ZEMAN, RJ

ZHANG, Y

ETLINGER, JD

机构：

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1994年 / 267卷 / 03期

关键词：

PROTEIN; MYOSIN; TWITCH; TETANUS; CROSS-SECTIONAL AREA; MOUSE;

D O I：

10.1152/ajpcell.1994.267.3.C865

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Treatment with the adrenergic beta(2)-receptor agonist clenbuterol prevented, in dystrophic muscle from mdx mice, a pronounced loss of contractile strength that is observed after blockade of muscle regeneration with gamma irradiation. In addition, muscle mass and myosin content were greater (62-109%) in irradiated hindlimbs from clenbuterol-treated melic mice, whereas the effects of the beta(2)-agonist were relatively smaller (12-21%) in the nonirradiated hindlimbs. Together, these results suggest that beta(2)-agonists can antagonize degenerative processes occurring in muscle fibers lacking dystrophin.

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收藏

页码：C865 / C868

页数：4

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