Synergy of iron in the toxicity and carcinogenicity of polychlorinated biphenyls (PCBs) and related chemicals

被引：29

作者：

Smith, AG

Carthew, P

Clothier, B

Constantin, D

Francis, JE

Madra, S

机构：

[1] MRC Toxicolgy Unit, University of Leicester, Leicester, LE1 9HN, Lancaster Road

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

iron; PCBs; hepatic porphyria; liver cancer;

D O I：

10.1016/0378-4274(95)03530-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

In Ah-responsive C57BL/10ScSn mice a single dose of iron significantly potentiated the property of the polychlorinated biphenyl (PCB) mixture Aroclor 1254 to induce porphyria by inhibition at the uroporphyrinogen decarboxylase stage of hepatic haem biosynthesis. The induction of liver tumors and other lesions were also enhanced markedly by iron overload suggesting a link between porphyria and cancer. The cellular, molecular and biochemical processes involved have been investigated in attempts to explain these phenomena by an iron-catalysed 'oxidative stress' mechanism.

引用

页码：945 / 950

页数：6

共 20 条

[1] INDUCTION OF 8-HYDROXYDEOXYGUANOSINE IN AH-RESPONSIVE MOUSE-LIVER BY IRON AND AROCLOR 1254 [J].