OXIDATION OF RAT INSULIN-II, BUT NOT I, LEADS TO ANOMALOUS ELUTION PROFILES UPON HPLC ANALYSIS OF INSULIN-RELATED PEPTIDES

被引:21
作者
GROSS, D
SKVORAK, A
HENDRICK, G
WEIR, G
VILLAKOMAROFF, L
HALBAN, P
机构
[1] UNIV GENEVA,SCH MED,CTR MED,RECH LOUIS JEANTET LABS,1 RUE MICHEL SERVET,CH-1211 GENEVA 4,SWITZERLAND
[2] HARVARD UNIV,SCH MED,JOSLIN DIABET CTR,BOSTON,MA 02115
[3] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,BOSTON,MA 02115
[4] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT NEUROSCI,BOSTON,MA 02115
关键词
D O I
10.1016/0014-5793(88)81062-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:205 / 208
页数:4
相关论文
共 15 条
  • [1] PROINSULIN RADIOIMMUNOASSAY IN THE EVALUATION OF INSULINOMAS AND FAMILIAL HYPERPROINSULINEMIA
    COHEN, RM
    GIVEN, BD
    LICINIOPAIXAO, J
    PROVOW, SA
    RUE, PA
    FRANK, BH
    ROOT, MA
    POLONSKY, KS
    TAGER, HS
    RUBENSTEIN, AH
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1986, 35 (12): : 1137 - 1146
  • [2] DIFFERENTIAL KINETICS OF RAT INSULIN-I AND INSULIN-II PROCESSING IN RAT ISLETS OF LANGERHANS
    GISHIZKY, ML
    GRODSKY, GM
    [J]. FEBS LETTERS, 1987, 223 (02) : 227 - 231
  • [3] BIOCHEMICAL AND CLINICAL IMPLICATIONS OF PROINSULIN CONVERSION INTERMEDIATES
    GIVEN, BD
    COHEN, RM
    SHOELSON, SE
    FRANK, BH
    RUBENSTEIN, AH
    TAGER, HS
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (04) : 1398 - 1405
  • [4] GROSS DJ, 1988, DIABETES S1, V37, pA48
  • [5] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY (HPLC) - A RAPID, FLEXIBLE AND SENSITIVE METHOD FOR SEPARATING ISLET PROINSULIN AND INSULIN
    HALBAN, PA
    RHODES, CJ
    SHOELSON, SE
    [J]. DIABETOLOGIA, 1986, 29 (12) : 893 - 896
  • [6] COATED CHARCOAL IMMUNOASSAY OF INSULIN
    HERBERT, V
    LAU, KS
    GOTTLIEB, CW
    BLEICHER, SJ
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1965, 25 (10) : 1375 - +
  • [7] KAWAZOE I, 1987, INT J PEPT PROT RES, V29, P714
  • [8] LINDE S, IN PRESS J CHROMATOG
  • [9] Neumann N.P., 1967, METHOD ENZYMOL, V11, P485, DOI 10.1016/S0076-6879(67)11057-4
  • [10] GLUCOSE STIMULATES THE BIOSYNTHESIS OF RAT-I AND RAT-II INSULIN TO AN EQUAL EXTENT IN ISOLATED PANCREATIC-ISLETS
    RHODES, CJ
    LUCAS, CA
    HALBAN, PA
    [J]. FEBS LETTERS, 1987, 215 (01) : 179 - 182