PHYSIOLOGIC SURFACE-ACTIVE AGENTS AND DRUG ABSORPTION .2. COMPARISON OF EFFECT OF SODIUM TAURODEOXYCHOLATE AND ETHYLENEDIAMINETETRAACETIC ACID ON SALICYLAMIDE AND SALICYLATE TRANSFER ACROSS EVERTED RAT SMALL INTESTINE

The effect of sodium taurodeoxycholate (STDC) and ethylenediaminetetraacetic acid (EDTA) on the transfer of salicylamide and salicylate across the everted rat intestine was studied. STDC produces a small but statistically significant increase (11–21%) in the intestinal transfer rate of salicylamide over a concentration range of 5–100 mM but has no measurable effect at a 1 mM concentration. There is a small but statistically significant increase (about 20%) in the intestinal transfer rate of salicylate after the intestine has been exposed to 25 mM EDTA but the chelating agent has no significant effect on salicylamide transfer. The results indicate that both EDTA and STDC alter membrane structure and thereby affect permeability but by two different mechanisms. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company