ALLELE-SPECIFIC MOTIFS REVEALED BY SEQUENCING OF SELF-PEPTIDES ELUTED FROM MHC MOLECULES

被引：2316

作者：

FALK, K ^{[1
]}

ROTZSCHKE, O ^{[1
]}

STEVANOVIC, S ^{[1
]}

JUNG, G ^{[1
]}

RAMMENSEE, HG ^{[1
]}

机构：

[1] UNIV TUBINGEN, INST ORGAN CHEM, W-7400 TUBINGEN 1, GERMANY

来源：

NATURE | 1991年 / 351卷 / 6324期

关键词：

D O I：

10.1038/351290a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the grove adhere.

引用

页码：290 / 296

页数：7

共 47 条

[1] USE OF SYNTHETIC PEPTIDES OF INFLUENZA NUCLEOPROTEIN TO DEFINE EPITOPES RECOGNIZED BY CLASS-I-RESTRICTED CYTOTOXIC LYMPHOCYTES-T
BASTIN, J
ROTHBARD, J
DAVEY, J
JONES, I
TOWNSEND, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (06) : 1508 - 1523
[2] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2
BJORKMAN, PJ
SAPER, MA
SAMRAOUI, B
BENNETT, WS
STROMINGER, JL
WILEY, DC
[J]. NATURE, 1987, 329 (6139) : 506 - 512
[3] THE FOREIGN ANTIGEN-BINDING SITE AND T-CELL RECOGNITION REGIONS OF CLASS-I HISTOCOMPATIBILITY ANTIGENS
BJORKMAN, PJ
SAPER, MA
SAMRAOUI, B
BENNETT, WS
STROMINGER, JL
WILEY, DC
[J]. NATURE, 1987, 329 (6139) : 512 - 518
[4] BJORKMAN PJ, 1989, COLD SPRING HARB SYM, V54, P365
[5] PHYSICAL ASSOCIATION BETWEEN MHC CLASS-I MOLECULES AND IMMUNOGENIC PEPTIDES
BOUILLOT, M
CHOPPIN, J
CORNILLE, F
MARTINON, F
PAPO, T
GOMARD, E
FOURNIEZALUSKI, MC
LEVY, JP
[J]. NATURE, 1989, 339 (6224) : 473 - 475
[6] CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED CYTOLYTIC LYMPHOCYTES-T RECOGNIZE A LIMITED NUMBER OF SITES ON THE INFLUENZA HEMAGGLUTININ
BRACIALE, TJ
SWEETSER, MT
MORRISON, LA
KITTLESEN, DJ
BRACIALE, VL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (01) : 277 - 281
[7] ON THE ROLE OF THE TRANSMEMBRANE ANCHOR SEQUENCE OF INFLUENZA HEMAGGLUTININ IN TARGET-CELL RECOGNITION BY CLASS-I MHC-RESTRICTED, HEMAGGLUTININ-SPECIFIC CYTOLYTIC LYMPHOCYTES-T
BRACIALE, TJ
BRACIALE, VL
WINKLER, M
STROYNOWSKI, I
HOOD, L
SAMBROOK, J
GETHING, MJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (03) : 678 - 692
[8] INDUCTION OF OVALBUMIN-SPECIFIC CYTO-TOXIC T-CELLS BY INVIVO PEPTIDE IMMUNIZATION
CARBONE, FR
BEVAN, MJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (03) : 603 - 612
[9] PRESENTATION OF VIRAL-ANTIGEN CONTROLLED BY A GENE IN THE MAJOR HISTOCOMPATIBILITY COMPLEX
CERUNDOLO, V
ALEXANDER, J
ANDERSON, K
LAMB, C
CRESSWELL, P
MCMICHAEL, A
GOTCH, F
TOWNSEND, A
[J]. NATURE, 1990, 345 (6274) : 449 - 452
[10] T-IMMUNOGENIC PEPTIDES ARE CONSTITUTED OF RARE SEQUENCE PATTERNS - USE IN THE IDENTIFICATION OF T-EPITOPES IN THE HUMAN IMMUNODEFICIENCY VIRUS GAG PROTEIN
CLAVERIE, JM
KOURILSKY, P
LANGLADEDEMOYEN, P
CHALUFOURPROCHNICKA, A
DADAGLIO, G
TEKAIA, F
PLATA, F
BOUGUELERET, L
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (10) : 1547 - 1553

← 1 2 3 4 5 →