TIME OF SUPPRESSION OF HUMAN RIBOSOMAL-RNA GENES IN MOUSE-HUMAN HYBRID-CELLS

被引：17

作者：

DEV, VG

MILLER, DA

RECHSTEINER, M

MILLER, OJ

机构：

[1] COLUMBIA UNIV, DEPT HUMAN GENET & DEV, NEW YORK, NY 10032 USA

[2] UNIV UTAH, DEPT BIOL, SALT LAKE CITY, UT 84112 USA

[3] COLUMBIA UNIV, CTR CANC, INST CANC RES, NEW YORK, NY 10032 USA

[4] COLUMBIA UNIV, DEPT OBSTET & GYNECOL, NEW YORK, NY 10032 USA

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 123卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0014-4827(79)90419-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In mouse-human hybrids that were destined to lose human chromosomes, Ag-stained nucleolus organizer regions (NOR) were present on both human and mouse chromosomes in metaphase cells harvested during the 1st few days after fusion. The amount of Ag stain on the human NOR decreased gradually and disappeared by about 12 days, presumably reflecting suppression of the transcriptional activity of the human rRNA genes. The time of disappearance of human NOR depended on the relative number of mouse and human chromosomes in the hybrid cells and on the type of parental cells. It was not closely correlated with loss of human chromosomes.

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页码：47 / 54

页数：8

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