ENZYME-CATALYZED REACTIONS .5. ENZYME-CATALYZED SYNTHESIS OF (S)-CYANOHYDRINS AND SUBSEQUENT HYDROLYSIS TO (S)-ALPHA-HYDROXY-CARBOXYLIC ACIDS

被引:93
作者
EFFENBERGER, F
HORSCH, B
FORSTER, S
ZIEGLER, T
机构
[1] Institut für Organische Chemie, Universität Stuttgart Pfaffenwaldring 55
关键词
D O I
10.1016/S0040-4039(00)88777-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(S)-Cyanohydrins 2 are obtained with high enantioselectivity from aromatic aldehydes and HCN in the presence of (S)-oxynitrilase (E.C.4.1.2.11). Acid-catalyzed hydrolysis of the cyanohydrins 2 affords the corresponding (S)-α-hydroxy carboxylic acids 3 without racemization. © 1990.
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页码:1249 / 1252
页数:4
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