URICOSURIC RESPONSE TO INCREASING DOSES OF THE INDANONE DIURETIC MK-196 IN HEALTHY-VOLUNTEERS

被引：6

作者：

EMMERSON, BT ^{[1
]}

THOMPSON, L ^{[1
]}

MITCHELL, K ^{[1
]}

机构：

[1] UNIV QUEENSLAND, PRINCESS ALEXANDRA HOSP, DEPT MED, BRISBANE 4000, Qld, AUSTRALIA

来源：

NEPHRON | 1979年 / 23卷

关键词：

D O I：

10.1159/000181666

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Doses of 20, 40, 60 and 80 mg of the indanone diuretic MK-196 and 40 mg of frusemide were administered in random order to 5 healthy volunteers in a stable metabolic state, on the same day for 5 consecutive weeks. Diuresis, natriuresis and kaluresis with increasing doses, the natriuresis lasting for about 12 hr and the kaluresis for about 24 hr. Uricosuria increased with increasing doses of MK-196 and lasted for about 6 hr. The uricosuria was followed by urate retention, so that there was little net change in the renal excretion of urate. Significant weight loss occurred, so that there was probably some associated plasma volume contraction, which would promote urate retention. By contrast, frusemide caused a reduction in renal excretion of urate at all times.

引用

页码：38 / 40

页数：3