ACTIVITY OF GAMMA-INTERFERON IN COMBINATION WITH PYRIMETHAMINE OR CLINDAMYCIN IN TREATMENT OF MURINE TOXOPLASMOSIS

被引：17

作者：

ISRAELSKI, D ^{[1
]}

REMINGTON, J ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV INFECT DIS,STANFORD,CA 94305

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1990年 / 9卷 / 05期

关键词：

D O I：

10.1007/BF01973746

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The activity of recombinant gamma interferon (rIFN-γ) in combination with either pyrimethamine or clindamycin was examined in a murine model of acute toxoplasmosis. Mice received either pyrimethamine or clindamycin alone or in combination with rIFN-γ. Significantly increased survival and/or time to death was observed in animals treated with pyrimethamine or clindamycin in combination with rIFN-γ compared to those that received treatment with any of the agents alone. © 1990 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

引用

页码：358 / 361

页数：4

共 10 条

[1] EFFECT OF CLINDAMYCIN ON ACUTE AND CHRONIC TOXOPLASMOSIS IN MICE
ARAUJO, FG
REMINGTO.JS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1974, 5 (06) : 647 - 651
[2] IMMUNOHISTOLOGICAL STUDY OF THE ANATOMIC RELATIONSHIP OF TOXOPLASMA ANTIGENS TO THE INFLAMMATORY RESPONSE IN THE BRAINS OF MICE CHRONICALLY INFECTED WITH TOXOPLASMA-GONDII
CONLEY, FK
JENKINS, KA
[J]. INFECTION AND IMMUNITY, 1981, 31 (03) : 1184 - 1192
[3] TREATMENT OF TOXOPLASMIC ENCEPHALITIS WITH INTRAVENOUS CLINDAMYCIN
DANNEMANN, BR
ISRAELSKI, DM
REMINGTON, JS
[J]. ARCHIVES OF INTERNAL MEDICINE, 1988, 148 (11) : 2477 - 2482
[4] INVIVO SYNERGISM OF ROXITHROMYCIN (RU-965) AND INTERFERON AGAINST TOXOPLASMA-GONDII
HOFFLIN, JM
REMINGTON, JS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (02) : 346 - 348
[5] CLINDAMYCIN IN A MURINE MODEL OF TOXOPLASMIC ENCEPHALITIS
HOFFLIN, JM
REMINGTON, JS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (04) : 492 - 496
[6] ZIDOVUDINE ANTAGONIZES THE ACTION OF PYRIMETHAMINE IN EXPERIMENTAL-INFECTION WITH TOXOPLASMA-GONDII
ISRAELSKI, DM
TOM, C
REMINGTON, JS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (01) : 30 - 34
[7] LEPORT C, 1988, PRESSE MED, V17, P1813
[8] EFFECT OF MURINE INTERFERON GAMMA ON MURINE TOXOPLASMOSIS
MCCABE, RE
LUFT, BJ
REMINGTON, JS
[J]. JOURNAL OF INFECTIOUS DISEASES, 1984, 150 (06) : 961 - 962
[9] MURRAY HW, 1987, J IMMUNOL, V138, P2457
[10] INTERFERON-GAMMA - THE MAJOR MEDIATOR OF RESISTANCE AGAINST TOXOPLASMA-GONDII
SUZUKI, Y
ORELLANA, MA
SCHREIBER, RD
REMINGTON, JS
[J]. SCIENCE, 1988, 240 (4851) : 516 - 518

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